2023 IADR/LAR General Session with WCPD
The 2023 IADR/LAR General Session & Exhibition with WCPD provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Bogotá, Colombia. The meeting was attended by 1,667 individuals from 76 countries.The recordings in this library from the meeting are a selection of the science that was presented at the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
Inflamed pulp due to chemical, mechanical, or microbial aggression, and once the etiology has been controlled, the possibility of reestablishing homeostasis depends mainly on achieving the regulation of the immune response in the pulp microenvironment. Preparations for crowns or deep cavities generate inflammatory reactions in the dental pulp, which can be reversible, favoring tissue repair. However, if they are not early controlled, they become irreversible and cause necrosis, leading to tissue loss.
Immunomodulation therapies can then be used to maintain the pulp vitality. Different models allow us to understand the inflammatory responses at the pulp level, mediated mainly by immune cells, including M1 macrophages, the T effectors lymphocyte, cytokines, plasma proteins, and neuropeptides. In order to control the exacerbated pulp response, the use of phytomedicines can be the first step for pulp repair and regeneration. The main mechanisms for immunomodulation-induction are M2 macrophages and regulatory T cells and neuropeptides as VIP.
On the other hand, mesenchymal stem cells characterized in vivo and in vitro models can deliver immunoregulatory cytokines in their secretome with potent proangiogenic effects. Potentiating its role in situ or by the direct application of this secretome induced in vitro in direct injuries, could be a significant step to promote pulpar repair.
This symposium provides helpful in vitro and animal models that contribute to understanding the knowledge of immunological challenges, such as the importance of preserving pulp vitality. Based on phytomedicines and products of constitutive mesenchymal stem cells.
Learning Objectives
Thursday, June 22, 2023
Session Organizer/Chair
Nelly Roa (Corresponding Organizer)
Tatiana Botero (Organizer/Chair)
Presenters
Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
Inflamed pulp due to chemical, mechanical, or microbial aggression, and once the etiology has been controlled, the possibility of reestablishing homeostasis depends mainly on achieving the regulation of the immune response in the pulp microenvironment. Preparations for crowns or deep cavities generate inflammatory reactions in the dental pulp, which can be reversible, favoring tissue repair. However, if they are not early controlled, they become irreversible and cause necrosis, leading to tissue loss.
Immunomodulation therapies can then be used to maintain the pulp vitality. Different models allow us to understand the inflammatory responses at the pulp level, mediated mainly by immune cells, including M1 macrophages, the T effectors lymphocyte, cytokines, plasma proteins, and neuropeptides. In order to control the exacerbated pulp response, the use of phytomedicines can be the first step for pulp repair and regeneration. The main mechanisms for immunomodulation-induction are M2 macrophages and regulatory T cells and neuropeptides as VIP.
On the other hand, mesenchymal stem cells characterized in vivo and in vitro models can deliver immunoregulatory cytokines in their secretome with potent proangiogenic effects. Potentiating its role in situ or by the direct application of this secretome induced in vitro in direct injuries, could be a significant step to promote pulpar repair.
This symposium provides helpful in vitro and animal models that contribute to understanding the knowledge of immunological challenges, such as the importance of preserving pulp vitality. Based on phytomedicines and products of constitutive mesenchymal stem cells.
Learning Objectives
- Identify mesenchymal stem cells obtained from dental pulp in human and animal models.
- Know the inflammatory events in a pulp after aggression to understand the mechanisms of immunomodulation
- Identify mesenchymal stem cells obtained from dental pulp in human and animal models.
- Know the inflammatory events in a pulp after aggression to understand the mechanisms of immunomodulation
- Analyse the need to use platelet-rich plasma, platelet-rich fibrin, or platelet lysate as adjuvant therapy in pulpal regeneration
Thursday, June 22, 2023
Session Organizer/Chair
Nelly Roa (Corresponding Organizer)
Tatiana Botero (Organizer/Chair)
Presenters
- Nelly Roa - o Induction of Regulatory T cells Using Phytomedicine for Pulp Immunomodulation
- Lorenza Jaramillo - Pulpal mesenchymal Cells, an Opportunity For Immunomodulation
- Henry Sossa - Immunomodulation of the Pulp Microenvironment
Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
NONE
Not eligible for individual purchase must purchase as part of a meeting bundle.
