2023 IADR/LAR General Session with WCPD
The 2023 IADR/LAR General Session & Exhibition with WCPD provided dental, oral, and craniofacial health scientists with the opportunity to present, discuss, and critique their latest and most cutting-edge research at a 100% in-person gathering in Bogotá, Colombia. The meeting was attended by 1,667 individuals from 76 countries.The recordings in this library from the meeting are a selection of the science that was presented at the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include IADR Distinguished Lecture Series speakers and symposia from a collection of scientific groups and networks.
This session can be purchased as part of the full meeting recordings within the product bundles
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Session Description
The biology of the dental pulp is complex with the intertwined role of immune cells, endothelial cells, fibroblasts, stem cells, and sensory neurons. A study of an isolated target often undermines the role of its counterparts in the development and pathogenesis of pulpitis, wound healing, and pulp regeneration. Moreover, there exist significant variances between patient phenotypes based on sex and clinical presentation. For example, 57% of patients with apical periodontitis experience pain while the other cohort, despite similar clinical presentation are asymptomatic. Finally, there is poor clinical translatability from animal studies to humans. Our symposium aims to present high throughput datasets generated from human tissues using transcriptomic profiling as well as connectivity mapping of genes for gene-based therapies for dental pulp healing, regeneration, and nociception. Specifically, we will present work that discusses pain phenotypes in male and female patients, gene mapping for the identification of targets for the treatment of pulpitis, and tooth-type specific sequencing that aid in precision-based dentistry.
Learning Objectives
Wednesday, June 21, 2023
Session Organizer/Chair
Hal Duncan (Organizer)
Nikita Ruparel (Organizer/Chair)
Presenters
Neuroscience|Stem Cell Biology Research|Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
Financial Interest Disclosure:
NONE
The biology of the dental pulp is complex with the intertwined role of immune cells, endothelial cells, fibroblasts, stem cells, and sensory neurons. A study of an isolated target often undermines the role of its counterparts in the development and pathogenesis of pulpitis, wound healing, and pulp regeneration. Moreover, there exist significant variances between patient phenotypes based on sex and clinical presentation. For example, 57% of patients with apical periodontitis experience pain while the other cohort, despite similar clinical presentation are asymptomatic. Finally, there is poor clinical translatability from animal studies to humans. Our symposium aims to present high throughput datasets generated from human tissues using transcriptomic profiling as well as connectivity mapping of genes for gene-based therapies for dental pulp healing, regeneration, and nociception. Specifically, we will present work that discusses pain phenotypes in male and female patients, gene mapping for the identification of targets for the treatment of pulpitis, and tooth-type specific sequencing that aid in precision-based dentistry.
Learning Objectives
- Describe the use of metadata for clinical translational research
- Describe the validation of metadata using molecular approaches
- Describe novel targets involved in pulpitis and pulp regeneration
Wednesday, June 21, 2023
Session Organizer/Chair
Hal Duncan (Organizer)
Nikita Ruparel (Organizer/Chair)
Presenters
- Michael Eskander - Differential Regulation of Pain and Sex Differences as Highlighted by Transcriptomic Profiling
- Ikhlas El Karim - Identification of Novel Markers and Therapeutics for Pulpitis using Connectivity Mapping
- Thantrira Porntaveetus - Tooth Specific Gene-based therapies for Pulp Regeneration
Neuroscience|Stem Cell Biology Research|Pulp Biology & Regeneration Research
CE Credits
1.5 Hours
NONE