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Novel Vascularization Strategies in Craniofacial Tissue Regeneration

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2022 IADR/APR General Session

The 100 th General Session & Exhibition of the IADR was held in conjunction with the 5th Meeting of the Asia Pacific Region. The virtual meeting was attended by individuals from around the world. Those attending the meeting could choose from among 207 Interactive Talk sessions, seven Focused Learning Sessions, three Hands-on Workshops, five satellite symposia, 52 Symposia, one Distinguished Lecture Series and a plenary. 

The recordings in this library from the meeting are a selection of the science that was to be presented as part of the General Session. These recordings give you the opportunity to participate in the meeting and hear from leading researchers. The recordings include the IADR Distinguished Lecture Series speaker and symposia from a collection of scientific groups and networks.

This session can be purchased as part of the full meeting recordings within the product bundles





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Session Description 
Reestablishment of an elaborated vascular network is one of the main focuses in the research in regeneration of craniofacial tissues. In this symposium, we will share our research insights on current challenges and efforts particularly in vascularization strategies in craniofacial tissue regeneration.

A microenvironment of ischemia and hypoxia in the biomaterial core drives propagation, differentiation and reorganization of progenitor/stem cells to assemble into a primitive microvascular framework. We will discuss the interaction of collagen-containing biomaterials with the host in achieving revascularization in these instances. Vascular biological aspects will also be discussed to identify key biomechanical factors controlling blood vessel functionality. In addition, we focus on prevascularization strategies and delivery of vasculogenic molecules that enhance endothelial differentiation and stimulation of the host regenerative response to promote vessel sprouting and strength.

In order to optimize structural and vascular integration, well-designed microstructures of scaffolds are impertinent. Proper porous structures, matrix stiffness, and surface morphology of scaffolds have a profound influence on cell behaviors and subsequent revascularization. Therefore, advanced techniques such as 3D printing of bio-scaffolds, cell laden hydrogels and microfluidic devices that are at the forefront of novel revascularization strategies will be discussed. Finally, we will focus on how these techniques can be utilized in generating functional vasculature for potential translational and therapeutic purposes of craniofacial soft as well as mineralized tissue regeneration.

Learning Objectives
  • To understand the importance of developing novel strategies of vascularization in craniofacial regeneration
  • To recognize the latest cutting-edge techniques utilized in achieving vascularization in craniofacial research
  • To identify challenges and solutions in achieving functional vascularization in potential translational craniofacial regeneration

Presentation Date
June 25, 2022

Presenters
Imad About - Induction of Angiogenesis and Stem Cell Recruitment via Complement Activation
Waruna Dissanayaka - Utilizing Microenvironmental Cues in Promoting Vascularization During Tissue Regeneration
Luiz Bertassoni - 3D Printed Cell-Laden Hydrogels and Microfluidic Devices in Vascularization
Yoontae Kim - 3D Printing Technology to Build Vascularized Tissues

Sponsoring Groups/Networks
Mineralized Tissue, Pulp Biology & Regeneration Research, Stem Cell Biology Research

CE Credits
1.5 Hours

Financial Interest Disclosure:
None


Not eligible for individual purchase; must purchased as part of a meeting bundle.