Program Overview
Many women experience abdominal and pelvic pain related to their menstrual cycle or endometriosis. Yet for some women, these symptoms are due to a group of inherited diseases known as acute hepatic porphyria (AHP). On average, patients spend 15 years misdiagnosed and undergoing numerous medical tests and visits with specialists. This activity will explore how to differentially diagnose patients with unexplained pelvic pain, strategies for confirming a suspected diagnosis of AHP, and available treatments options to ensure early diagnosis and optimal outcomes.

Target Audience
This initiative is intended for obstetrics/gynecologic (OB/GYN) physicians, nurses, physician assistants and other healthcare professionals assessing patients in the OB/GYN setting.

Educational Objectives
Upon completion of this activity, the learner should be able to:

• Explain the etiology and pathophysiology of AHP as a cause of severe abdominal/pelvic pain among women
• Identify signs and symptoms suggestive of AHP that may present in women seeking OB/GYN care
• Define appropriate strategies to screen and diagnose AHP among OB/GYN patients
• Recognize the impact that the menstrual cycle- and medication-induced hormonal changes have on AHP attacks
• Assess the clinical utility of disease-specific therapies for preventing AHP attacks in women
• Propose interdisciplinary strategies to individualize clinical management of AHP in the OB/GYN setting

AGENDA

• Introduction
• Recognizing Potential AHP in the OB/GYN Setting: Clinical Assessment
• Strategies for Screening AHP and Reaching a Differential Diagnosis
• Improving AHP Management in Women: Identifying and Mitigating Triggers and Implementing Disease-Specific Therapy
• Q&A

Karl E. Anderson, MD, FACP
Professor, Departments of Internal Medicine (Division of Gastroenterology and Hepatology) and Preventive Medicine and Population Health
Director, Clinical Science Graduate Program
Director, Porphyria Laboratory and Center
Member, Institute for Translational Sciences
University of Texas Medical Branch/UTMB Health
Galveston, TX

D. Montgomery Bissell, MD
Professor of Medicine, Emeritus
Department of Medicine
Director Emeritus, UCSF Liver Center
San Francisco, CA

Herbert Lloyd Bonkovsky, MD
Professor of Medicine and Molecular Medicine and Translational Research and Director of the Liver and Metabolic Disorders Laboratory
Wake Forest University School of Medicine
Winston Salem, NC

Disclosure.
It is the policy of AKH Inc. to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. The author must disclose to the participants any significant relationships with ineligible companies whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are mitigated by AKH prior to accreditation of the activity. AKH planners and reviewers have no relevant financial relationships to disclose.

CRITERIA FOR SUCCESS
Certificates of completion will be awarded based on the participant’s attendance and submission of the activity evaluation/claim credit form. You must participate in the entire activity to receive credit. There is no fee to participate in this activity. If you have questions about this activity, please contact AKH Inc. at tbrignoni@akhcme.com.

Credit provided by AKH Inc., Advancing Knowledge in Healthcare


In support of improving patient care, this activity has been planned and implemented by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians
AKH Inc., Advancing Knowledge in Healthcare designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician Assistants
 AKH Inc., Advancing Knowledge in Healthcare has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

Nurses
1.5 ANCC contact hours

Provider Information
This program is jointly provided by AKH Inc., Advancing Knowledge in Healthcare and Catalyst Medical Education, LLC

Commercial Support:
This activity is supported by an educational grant from Alnylam Pharmaceuticals, Inc.

Disclaimer
This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaim responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Disclosure of Unlabeled Use and Investigational Product
This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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